Description

L-Aile-L-Pro-n-Methyl-Gly-n-Methyl-L-Val-Ome is a specialized, non-natural amino acid derivative with a complex, constrained peptide-like structure. This compound is of significant value in advanced pharmaceutical research and development, particularly in the design of novel peptide-based therapeutics and diagnostics. It serves as a critical building block for medicinal chemists and researchers in the biotechnology and pharmaceutical industries seeking to modulate peptide conformation, stability, and biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex peptide drugs and peptidomimetics.
• Drug Discovery Research: Used in structure-activity relationship (SAR) studies to develop new active pharmaceutical ingredients (APIs) with improved metabolic stability and receptor selectivity.
• Peptide Engineering: Incorporation into peptide sequences to introduce conformational constraints (e.g., for α-helix or β-turn stabilization) and enhance pharmacological properties.
• Bioconjugation & Probe Development: Serves as a specialized linker or component in the development of fluorescent probes, affinity labels, and targeted drug conjugates.
• Academic & Contract Research: Utilized in university and CRO (Contract Research Organization) laboratories for fundamental research in bioorganic chemistry and chemical biology.

Basic Information

Product Name	L-Aile-L-Pro-n-Methyl-Gly-n-Methyl-L-Val-Ome
CAS No.	55555-43-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	L-Alanyl-L-prolyl-N-methylglycyl-N-methyl-L-valine methyl ester; Methyl L-alanyl-L-prolyl-N-methylglycyl-N-methyl-L-valinate; Aib-Pro-NMeGly-NMeVal-OMe (common abbreviation); Constrained tetrapeptide methyl ester derivative; N-methylated peptide analog
EINECS	Contact for details

Quality Control

Our production of L-Aile-L-Pro-n-Methyl-Gly-n-Methyl-L-Val-Ome adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive research applications. All materials are characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccation or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.