Description

5-Oxoprolyl-2,4(5)-Diiodohistidyl-Prolinamide is a specialized, high-purity peptide derivative with the CAS number 55536-96-4. This compound is valued for its unique iodinated histidine structure, which is critical for advanced research and development in pharmaceutical chemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in peptide-based drug discovery, biochemical studies, and the synthesis of novel bioactive molecules.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis of novel peptide-based therapeutics and drug candidates.
• Biochemical Research: Used as a tool compound in enzyme studies, receptor binding assays, and investigations into peptide-protein interactions due to its modified histidine moiety.
• Peptide Chemistry: Acts as a specialized building block for the solid-phase or solution-phase synthesis of complex, iodinated peptide sequences.
• Proteomics & Molecular Biology: Employed in the study of post-translational modifications and the development of specific biochemical probes.
• Academic Research: Utilized in university and institutional labs for fundamental research in medicinal chemistry and peptide science.
• Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control in peptide manufacturing.

Basic Information

Product Name	5-Oxoprolyl-2,4(5)-Diiodohistidyl-Prolinamide
CAS No.	55536-96-4
Molecular Formula	C19H23I2N7O5
Molecular Weight	715.24 g/mol
Synonyms	5-Oxo-L-prolyl-2,4(5)-diiodo-L-histidyl-L-prolinamide; L-Pyroglutamyl-2,4(5)-diiodo-L-histidyl-L-prolinamide; pGlu-His(2,4-I2)-Pro-NH2; TRH (2,4-Diiodo) derivative; Thyrotropin-Releasing Hormone (2,4-Diiodo-His) analog; 5-Oxo-Pro-His(2,4-I2)-Pro-NH2; pGlu-His(2,4-diI)-Pro-NH2; TRH Diiodo Analog
EINECS	Contact for details

Quality Control

Every batch of 5-Oxoprolyl-2,4(5)-Diiodohistidyl-Prolinamide is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, MS, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our commitment to quality supports research reproducibility and compliance with global standards for fine chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.