Description

Thyrotropin-Releasing Hormone, Linear β-Ala- is a synthetic peptide analog of the endogenous thyrotropin-releasing hormone (TRH). This compound is valued for its enhanced stability and specific biological activity, making it a critical tool in neuroendocrine and pharmaceutical research. It is primarily utilized by research institutions, diagnostic manufacturers, and pharmaceutical companies engaged in the development of neuroendocrine therapeutics and diagnostic assays.

Application

• Neuroendocrine Research: Used as a standard or probe in studies investigating the hypothalamic-pituitary-thyroid (HPT) axis, hormone release mechanisms, and receptor binding assays.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the R&D of novel TRH analogs for potential therapeutic applications in neurological and endocrine disorders.
• Diagnostic Manufacturing: Employed in the production and calibration of in-vitro diagnostic (IVD) kits and immunoassays designed to measure TRH or related pituitary hormones.
• Biochemical Studies: Applied in enzymatic stability studies and structure-activity relationship (SAR) research due to its modified linear structure with β-alanine.
• Cell Culture & In-Vitro Models: Used to stimulate thyrotropin (TSH) secretion in primary pituitary cell cultures or other relevant in-vitro biological systems.

Basic Information

Item	Detail
Product Name	Thyrotropin-Releasing Hormone, Linear β-Ala-
CAS No.	55536-95-3
Molecular Formula	C16H22N6O4
Molecular Weight	362.38 g/mol
Synonyms	TRH, Linear β-Ala-; L-Pyroglutamyl-L-histidyl-L-prolinamide, 3-(3-Aminopropanoyl)-; β-Alanine-TRH; (β-Ala3)-TRH; Linear TRH analog; Thyroliberin, Linear β-Ala- analog; Protirelin linear analog; 3-(3-Aminopropanoyl)-L-pyroglutamyl-L-histidyl-L-prolinamide
EINECS	Contact for details

Quality Control

Our Thyrotropin-Releasing Hormone, Linear β-Ala- is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing purity, peptide content, and residual solvent levels where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant in the container. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.