Description

1-(Hydroxymethyl)-5-Oxo-L-Proline is a high-purity, non-proteinogenic amino acid derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a versatile chiral building block and a key intermediate for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily utilized by research institutions, pharmaceutical development companies, and fine chemical manufacturers engaged in peptide mimetics, prodrug design, and the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, particularly in protease inhibitor and neurological drug research.
• Peptide Chemistry: Used in the design and synthesis of modified peptides and peptide mimetics to enhance stability, bioavailability, or biological activity.
• Prodrug Development: Serves as a promoiety or linker in prodrug strategies to improve the pharmacokinetic properties of parent drugs.
• Bioconjugation: Acts as a functional handle for linking drugs to antibodies, polymers, or other targeting molecules in ADC (Antibody-Drug Conjugate) and bioconjugate research.
• Chemical Biology Probes: Employed in the creation of specialized probes and tools for studying enzyme mechanisms and biological pathways.
• Fine Chemical Synthesis: A valuable intermediate in multi-step organic synthesis for creating complex, high-value specialty chemicals.

Basic Information

Item	Details
Product Name	1-(Hydroxymethyl)-5-Oxo-L-Proline
CAS No.	55525-34-3
Molecular Formula	C6H9NO4
Molecular Weight	159.14 g/mol
Synonyms	(S)-1-(Hydroxymethyl)-5-oxopyrrolidine-2-carboxylic acid; 5-Oxo-1-pyrrolidinecarboxylic acid, 1-(hydroxymethyl)-, (S)-; L-1-(Hydroxymethyl)-5-oxoproline; (S)-1-(Hydroxymethyl)-5-oxo-2-pyrrolidinecarboxylic acid; Hydroxymethyl-L-pyroglutamic acid; (2S)-1-(Hydroxymethyl)-5-oxopyrrolidine-2-carboxylic acid; 1-Hydroxymethyl-5-oxoproline; Pyroglutamic acid, 1-(hydroxymethyl)-, L-
EINECS	Contact for details

Quality Control

Our 1-(Hydroxymethyl)-5-Oxo-L-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements of research and development applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.