Description

Ecarin Immobilized CAS NO 55466-26-7 is a highly purified, stabilized enzyme preparation derived from the venom of *Echis carinatus* (saw-scaled viper), specifically engineered for covalent attachment to solid supports. This product is critical for developing robust, reusable diagnostic and research tools that require consistent and specific prothrombin activation. It is essential for manufacturers and research laboratories in the in-vitro diagnostics (IVD), hemostasis research, and pharmaceutical quality control sectors, where precise and reliable thrombin generation measurement is paramount.

Application

• Diagnostic Assay Manufacturing: Immobilization onto beads, plates, or sensor surfaces for use in automated coagulation analyzers and point-of-care testing devices.
• Thrombin Generation Testing (TGT): A key reagent in calibrated automated thrombogram (CAT) and other assays to measure thrombin potential in plasma samples.
• Research on Coagulation Pathways: Used in biochemical studies to specifically activate prothrombin, enabling the investigation of clotting mechanisms, inhibitors, and novel therapeutics.
• Quality Control for Anticoagulants: Employed in potency testing and lot-release assays for direct thrombin inhibitors (e.g., hirudin, argatroban).
• Biosensor Development: Integration into lab-on-a-chip and continuous monitoring systems for real-time detection of coagulation parameters.
• Purification Processes: As an affinity ligand immobilized on chromatography resins for the specific isolation of prothrombin or related proteins.

Basic Information

Product Name	Ecarin Immobilized CAS NO 55466-26-7
CAS No.	55466-26-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Ecarin (from Echis carinatus venom); Prothrombin activator ecarin; EC 3.4.21.-; Coagulation Factor II activator; Echis carinatus prothrombin activator; Immobilized Ecarin; Ecarin enzyme; Snake venom prothrombin activator
EINECS	Contact for details

Quality Control

Our Ecarin Immobilized is produced under stringent quality management systems. Each lot undergoes rigorous testing to ensure high specific activity, purity, and consistent immobilization efficiency. Quality parameters include activity assay, protein content, and assessment of leachables. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. Production adheres to relevant ISO 13485 guidelines for materials intended for in-vitro diagnostic use.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at 2-8°C. Avoid repeated freeze-thaw cycles. The product should be kept in a dry environment upon reconstitution or use.

Specification

Item	Specification
Appearance	Lyophilized powder or suspension (carrier-specific)
Identification (Activity)	Converts prothrombin to meizothrombin
Specific Activity	≥ [Value] units/mg protein
Protein Content (Biuret/Lowry)	Contact for details
Immobilization Matrix	Agarose, Magnetic beads, or other solid support
Carrier Concentration	Contact for details
Storage Buffer	Typically Tris or Phosphate buffer, pH ~7.4
Stabilizers	May contain sucrose, BSA, or other stabilizers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.