Description

n-[[Tricyclo[3.3.1.13,7]Decan-2-Yl]Carbonyl]-L-His-L-Leu-OMe is a specialized synthetic peptide derivative that incorporates the unique adamantane-based tricyclodecane structure. This compound is valued for its role as a key intermediate or building block in advanced pharmaceutical research and development, particularly in the design of novel bioactive molecules. It is primarily sought by research institutions and pharmaceutical companies engaged in peptide-based drug discovery, medicinal chemistry, and the synthesis of complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a critical building block for the synthesis of novel peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new therapeutic targets, particularly in areas like enzyme inhibition or receptor modulation.
• Bioconjugation & Probe Development: The adamantane moiety can be utilized for creating stable conjugates, labels, or molecular probes for diagnostic or research applications.
• Peptidomimetic Design: Acts as a scaffold for developing peptidomimetics, where the adamantane group enhances metabolic stability and membrane permeability.
• Academic & Industrial R&D: Employed in university and corporate laboratories for fundamental research in organic synthesis and peptide science.

Basic Information

Product Name	n-[[Tricyclo[3.3.1.13,7]Decan-2-Yl]Carbonyl]-L-His-L-Leu-OMe
CAS No.	55401-52-0
Molecular Formula	C26H40N6O4
Molecular Weight	500.64 g/mol
Synonyms	Adm-L-His-L-Leu-OMe; Adamantane-1-carbonyl-L-histidyl-L-leucine methyl ester; N-(1-Adamantylcarbonyl)-L-histidyl-L-leucine methyl ester; (S)-Methyl 2-((S)-2-(1-((adamantan-1-yl)carbonyl)amino)-3-(1H-imidazol-4-yl)propanamido)-4-methylpentanoate; Adamantoyl-His-Leu-OMe; 1-Adamantanecarbonyl-L-histidyl-L-leucine methyl ester; N-(Tricyclo[3.3.1.1³,⁷]decane-1-carbonyl)-L-histidyl-L-leucine methyl ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material that meets high-purity specifications suitable for research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. Quality assurance protocols are designed to support applications in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.