Description

L-Proline, 4-Mercoapto- (9Ci) is a specialized, non-proteinogenic amino acid derivative featuring a thiol functional group on the proline ring. This compound matters as a critical chiral building block and a versatile intermediate for synthesizing complex bioactive molecules, particularly in pharmaceutical research. It is needed by research scientists and process chemists in the pharmaceutical, biotechnology, and agrochemical industries for applications in drug discovery, peptide modification, and the development of enzyme inhibitors.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly protease inhibitors and other enzyme-targeted therapies.
• Peptide Chemistry & Modification: Used to introduce thiol functionality into peptide chains for conjugation, cyclization, or to create disulfide bonds, altering peptide stability and bioactivity.
• Bioconjugation & Probe Development: The reactive thiol group enables site-specific labeling of proteins, antibodies, or other biomolecules for diagnostic and research applications.
• Chemical Biology Research: Employed as a tool compound to study enzyme mechanisms, protein-ligand interactions, and metabolic pathways involving sulfur-containing amino acids.
• Agrochemical Synthesis: Acts as a chiral synthon in the development of advanced herbicides, fungicides, and plant growth regulators.
• Catalyst Ligand Synthesis: Utilized in the preparation of chiral ligands for asymmetric catalysis in fine chemical and API manufacturing.

Basic Information

Product Name	L-Proline, 4-Mercapto- (9Ci)
CAS No.	55309-60-9
Molecular Formula	C5H9NO2S
Molecular Weight	147.19 g/mol
Synonyms	(2S)-4-Sulfanylproline; (2S)-4-Mercaptoproline; 4-Thia-L-proline; L-4-Mercaptoproline; 4-Mercapto-L-proline; 4-SH-L-Proline; 4-Thiol-L-proline; 4-Mercapto-(S)-proline
EINECS	Contact for details

Quality Control

Our L-Proline, 4-Mercapto- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), and specific tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. Keep the container in a cool, dry, and well-ventilated place. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.