Description

Glutathionyldopa is a specialized biochemical compound formed from the conjugation of L-DOPA with the tripeptide glutathione. This molecule is of significant interest in biochemical and pharmaceutical research due to its role as a precursor and marker in melanogenesis and neuromelanin formation pathways. It is primarily utilized by research institutions and pharmaceutical developers focusing on neurodegenerative disease models, pigment metabolism, and advanced analytical method development. The compound is supplied under stringent quality controls to ensure consistency for critical research applications.

Application

• Biochemical Research: Used as a reference standard and substrate in studies investigating the biosynthesis and catabolism of neuromelanin in the brain.
• Neurodegenerative Disease Studies: Employed in model systems for Parkinson's disease to understand the role of dopamine-quinone and glutathione interactions in neuronal vulnerability.
• Analytical Chemistry: Serves as a high-purity calibrant and internal standard in HPLC, LC-MS, and other chromatographic methods for quantifying related metabolites in biological samples.
• Pigment Metabolism Research: Applied in studies of melanogenesis to elucidate pathways involving cysteinyl-dopas and their glutathione conjugates.
• Toxicology Investigations: Used to study the detoxification pathways of reactive dopamine quinones and oxidative stress mechanisms in cellular models.
• Pharmaceutical Development: Acts as a key intermediate or biomarker in the development of novel therapeutics targeting oxidative stress in neurological conditions.

Basic Information

Product Name	Glutathionyldopa
CAS No.	55136-58-8
Molecular Formula	C20H29N5O9S
Molecular Weight	539.54 g/mol
Synonyms	L-γ-Glutamyl-L-cysteinylglycyl-3,4-dihydroxy-L-phenylalanine; 5-S-Glutathionyldopa; Glutathionyl-DOPA; GSH-DOPA; γ-Glutamylcysteinylglycyl-3,4-dihydroxy-L-phenylalanine; Cysteinylglycyl-3,4-dihydroxy-L-phenylalanine conjugate with glutathione; (2S)-2-Amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-[(2S)-2-amino-2-carboxyethyl]disulfanyl]ethyl}carbamoyl}butanoic acid
EINECS	Contact for details

Quality Control

Every batch of Glutathionyldopa is produced and analyzed under a strict quality management system. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade standards and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA), detailing purity, identity, and impurity profiles, is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Unknown Impurity	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.