Description

Pglu-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-Nh2 is a synthetic peptide analog of gonadotropin-releasing hormone (GnRH). This compound is a critical research tool and pharmaceutical intermediate due to its potent biological activity and structural specificity. It is primarily utilized by biotechnology firms, pharmaceutical R&D laboratories, and academic institutions engaged in neuroendocrinology, oncology, and reproductive medicine research.

Application

• Pharmaceutical Research & Development: As a key intermediate or reference standard in the development of GnRH-based therapeutics for hormone-dependent cancers and reproductive disorders.
• Biochemical Assays: Used as a high-purity ligand in receptor binding studies and signal transduction pathway analysis to understand GnRH receptor interactions.
• Endocrinology Studies: A vital tool for investigating the hypothalamic-pituitary-gonadal axis, hormone regulation, and the development of diagnostic assays.
• Peptide Chemistry & Process Development: Serves as a model compound for optimizing solid-phase peptide synthesis (SPPS), purification (HPLC), and analytical method development.
• Academic & Contract Research: Supplied to universities and CROs for fundamental research in neuropeptides, molecular biology, and preclinical studies.

Basic Information

Product Name	Pglu-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-Nh2
CAS No.	54784-44-0
Molecular Formula	C64H86N18O15
Molecular Weight	1347.5 g/mol
Synonyms	GnRH Antagonist (Analog); [D-Phe2, D-Ala6]-GnRH; Pglu-His-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 analog; Gonadorelin Antagonist; Luteinizing Hormone-Releasing Hormone (LHRH) Analog; Pyroglutamyl-D-Phenylalanyl-Tryptophyl-Seryl-Tyrosyl-D-Alanyl-Leucyl-Arginyl-Prolyl-Glycinamide; 54784-44-0; Pglu-D-Phe2,D-Ala6-LHRH
EINECS	Contact for details

Quality Control

Our Pglu-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-Nh2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and tests for residual solvents and related substances. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom synthesis to meet specific purity requirements (e.g., >95%, >98%) is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 8.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.