Description

3-Bromo-1H-Pyrazolo[3,4-D]Pyrimidin-4-Ol is a high-value heterocyclic building block and key synthetic intermediate in medicinal chemistry. Its core structure is integral to the development of targeted kinase inhibitors, making it a critical raw material for pharmaceutical research and development. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents, particularly in oncology and inflammatory disease areas.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of small molecule kinase inhibitors, such as Bruton's tyrosine kinase (BTK) inhibitors.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Tool Compound Development: Used to create probes for studying specific enzyme pathways and cellular signaling mechanisms.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the multi-step synthesis of complex drug candidates targeting various disease pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug development pipelines.
• Academic Research: Used in university and institutional labs for fundamental research in heterocyclic chemistry and bioorganic chemistry.

Basic Information

Product Name	3-Bromo-1H-Pyrazolo[3,4-D]Pyrimidin-4-Ol
CAS No.	54738-73-7
Molecular Formula	C5H3BrN4O
Molecular Weight	214.99 g/mol
Synonyms	3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4-ol; 3-Bromo-4-hydroxy-1H-pyrazolo[3,4-d]pyrimidine; 4-Hydroxy-3-bromo-1H-pyrazolo[3,4-d]pyrimidine; 3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one; 3-Bromo-4(1H)-pyrazolo[3,4-d]pyrimidinone; BPP; 3-Bromo-4-hydroxypyrazolopyrimidine
EINECS	Contact for details

Quality Control

Our 3-Bromo-1H-Pyrazolo[3,4-D]Pyrimidin-4-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality commitment aligns with the standards expected by the pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.