Description

Sodium (S)-2-Hydroxy-3-Methylbutyrate is the sodium salt of the naturally occurring branched-chain amino acid metabolite, (S)-HMB. This compound matters as a stable and bioavailable form of HMB, a critical metabolite of the essential amino acid leucine, which is widely studied for its role in supporting muscle protein synthesis and reducing muscle breakdown. It is primarily needed by manufacturers in the sports nutrition, dietary supplement, and clinical nutrition sectors for formulating products aimed at muscle health, recovery, and lean mass support.

Application

• Sports Nutrition & Dietary Supplements: A key active ingredient in powders, capsules, and ready-to-drink formulations designed to enhance muscle recovery, support lean muscle mass, and improve exercise performance.
• Clinical Nutrition & Medical Foods: Used in specialized nutritional products for patients experiencing muscle wasting due to aging (sarcopenia), illness, or post-surgical recovery.
• Functional Food & Beverage Fortification: Incorporated into protein shakes, bars, and other fortified foods to provide added metabolic support for muscle maintenance.
• Animal Nutrition (Premixes): Applied in premium livestock and companion animal feed to promote lean growth and improve feed efficiency.
• Pharmaceutical Intermediates: Serves as a chiral building block or intermediate in the synthesis of more complex pharmaceutical compounds.
• Cosmetic & Personal Care: Explored for use in topical formulations aimed at improving skin firmness and health due to its role in protein metabolism.

Basic Information

Product Name	Sodium (S)-2-Hydroxy-3-Methylbutyrate
CAS No.	54641-19-9
Molecular Formula	C5H9NaO3
Molecular Weight	140.11 g/mol
Synonyms	(S)-2-Hydroxy-3-methylbutyric acid sodium salt; Sodium HMB; (S)-HMB sodium salt; β-Hydroxy β-methylbutyrate sodium salt; Calcium HMB alternative (sodium form); L-Leucine metabolite salt; 3-Hydroxy-3-methylbutanoic acid sodium salt (S-isomer); Sodium 3-hydroxy-3-methylbutyrate
EINECS	Contact for details

Quality Control

Our Sodium (S)-2-Hydroxy-3-Methylbutyrate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, correct stereochemistry, and compliance with relevant standards for dietary supplement ingredients. Certificates of Analysis (COA) documenting identity, assay, chiral purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive). Keep the container tightly sealed to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Chiral Purity ([α]D / HPLC)	≥ 99.0% (S)-isomer
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Microbiological Analysis	Meets standard dietary supplement criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.