Description

H-Thr-Glu-Oh is a high-purity, protected dipeptide building block, specifically L-Threonyl-L-Glutamic Acid, with the CAS registry number 54532-73-9. This compound is a critical intermediate for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics, enabling precise control over peptide chain assembly. It is essential for research and development laboratories, as well as production facilities in the pharmaceutical and biotechnology sectors, focused on creating novel therapeutic agents, diagnostic tools, and biochemical probes.

Application

• Pharmaceutical Intermediate: A key raw material in the synthesis of active pharmaceutical ingredients (APIs) for therapeutic peptides.
• Peptide Synthesis: Serves as a fundamental building block (Fmoc or Boc-protected) for automated and manual peptide synthesis.
• Biochemical Research: Used in structure-activity relationship (SAR) studies to develop novel enzyme inhibitors or receptor agonists/antagonists.
• Nutraceutical Development: Employed in the research of bioactive peptide sequences for functional food and supplement applications.
• Cosmetic Peptides: A precursor in the development of anti-aging or skin-repairing peptide sequences for advanced cosmetic formulations.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	H-Thr-Glu-Oh
CAS No.	54532-73-9
Molecular Formula	C9H16N2O6
Molecular Weight	248.23 g/mol
Synonyms	L-Threonyl-L-glutamic acid; H-Thr-Glu-OH; Thr-Glu; L-Thr-L-Glu; Threonylglutamic acid; (2S,3S)-2-[[(2S)-1,5-Dicarboxypentyl]amino]-3-hydroxybutanoic acid; Fmoc-Thr-Glu(OtBu)-OH (protected variant); Boc-Thr-Glu(OtBu)-OH (protected variant)
EINECS	Contact for details

Quality Control

Our H-Thr-Glu-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, optical rotation for chiral integrity, and residual solvent analysis. We provide full traceability and a detailed Certificate of Analysis (COA) with every shipment, ensuring compliance with your research and cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	-25° to -30° (c=1 in H2O)
Water Content (KF)	≤1.0%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.