Description

2-(Chloromethyl)Pyrimidine is a versatile and high-value pyrimidine derivative, serving as a critical building block in advanced organic synthesis. Its primary commercial value lies in its reactive chloromethyl group, which enables efficient functionalization and the construction of complex molecular architectures. This intermediate is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to develop active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of various active pharmaceutical ingredients (APIs), particularly those with pyrimidine-based cores, such as kinase inhibitors and antiviral agents.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and plant growth regulators that require the pyrimidine moiety for biological activity.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for metal-organic frameworks (MOFs) and catalysts for cross-coupling reactions.
• Material Science Research: Intermediate for synthesizing functionalized polymers, dyes, and photoactive compounds for electronic applications.
• Custom Chemical Synthesis: Serves as a starting material for contract research organizations (CROs) and CDMOs developing custom compounds for client projects.

Basic Information

Product Name	2-(Chloromethyl)Pyrimidine
CAS No.	54198-88-8
Molecular Formula	C5H5ClN2
Molecular Weight	128.56 g/mol
Synonyms	2-(Chloromethyl)pyrimidine; Pyrimidine, 2-(chloromethyl)-; 2-Pyrimidinylmethyl chloride; (Chloromethyl)pyrimidine; 2-Chloromethylpyrimidine; α-Chloromethylpyrimidine; NSC 403796; EINECS 259-045-5
EINECS	259-045-5

Quality Control

Our 2-(Chloromethyl)Pyrimidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.