Description

4-Chloro-5-Ethylpyrimidine is a versatile halogenated pyrimidine derivative, a key heterocyclic building block prized for its reactivity in organic synthesis. Its value lies in providing a functionalized scaffold for constructing more complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel compounds through targeted nucleophilic substitution and cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of various drug candidates, including kinase inhibitors, antiviral agents, and other biologically active molecules.
• Agrochemical Synthesis: Used as a building block for developing novel herbicides, fungicides, and insecticides, leveraging the pyrimidine core's bioactivity.
• Organic Synthesis Reagent: Serves as a versatile electrophile in cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic aromatic substitution reactions to introduce the pyrimidine moiety.
• Material Science Research: Employed in the development of organic electronic materials, ligands for catalysts, and other functional organic compounds.
• Chemical Reference Standard: Used in analytical laboratories for method development, calibration, and quality control testing of related substances.

Basic Information

Product Name	4-Chloro-5-Ethylpyrimidine
CAS No.	54128-01-7
Molecular Formula	C6H7ClN2
Molecular Weight	142.59 g/mol
Synonyms	5-Ethyl-4-chloropyrimidine; 4-Chloro-5-ethyl-pyrimidine; Pyrimidine, 4-chloro-5-ethyl-; 5-Ethyl-4-pyrimidinyl chloride
EINECS	Contact for details

Quality Control

Our 4-Chloro-5-Ethylpyrimidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the high standards required for synthetic applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.