Description

D-Proline, 1-(Aminocarbonyl)-4-Hydroxy-, cis- (9Ci) is a high-purity, non-proteinogenic amino acid derivative characterized by its specific stereochemistry and functional groups. This compound is a critical chiral building block and intermediate in advanced organic synthesis, valued for its role in constructing complex molecular architectures. It is primarily required by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and other fine chemicals where precise stereocontrol is essential.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new therapeutic agents, particularly for protease inhibitors and other targeted drugs.
• Peptidomimetics Research: Used to synthesize modified peptide structures that mimic natural peptides but with enhanced stability or biological activity.
• Asymmetric Synthesis: Acts as a precursor or catalyst component in stereoselective chemical reactions to produce enantiomerically pure compounds.
• Biochemical Research: Employed in studies of enzyme mechanisms, receptor-ligand interactions, and metabolic pathways involving proline derivatives.
• Agrochemical Development: Potential use as an intermediate in the synthesis of advanced, chiral crop protection agents.
• Material Science: Can be incorporated into specialty polymers or coatings to impart specific chiral or functional properties.

Basic Information

Product Name	D-Proline, 1-(Aminocarbonyl)-4-Hydroxy-, cis- (9Ci)
CAS No.	54080-04-5
Molecular Formula	C6H10N2O3
Molecular Weight	158.16 g/mol
Synonyms	cis-4-Hydroxy-D-proline carboxamide; (2R,4R)-4-Hydroxypyrrolidine-2-carboxamide; 4-Hydroxy-D-proline amide; D-cis-4-Hydroxyprolineamide; 1-Carbamoyl-4-hydroxy-D-proline; (4R)-4-Hydroxy-D-prolineamide; 54080-04-5; UNII-9K3F8S6F1P
EINECS	Contact for details

Quality Control

Our D-Proline, 1-(Aminocarbonyl)-4-Hydroxy-, cis- (9Ci) is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity (typically ≥98% by HPLC), and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.