Description

3-Maleimidopropionic Acid is a heterobifunctional crosslinking agent featuring a maleimide group and a carboxylic acid group, enabling selective conjugation with thiols and amines. This compound is essential for creating stable, site-specific bioconjugates in advanced research and therapeutic development. It is a critical building block for researchers and manufacturers in the fields of biopharmaceuticals, diagnostics, and materials science.

Application

• Bioconjugation and Protein Labeling: Site-specific conjugation of antibodies, peptides, and other proteins via thiol-maleimide chemistry for creating antibody-drug conjugates (ADCs) and diagnostic probes.
• Polymer and Biomaterial Modification: Functionalization of polymers, hydrogels, and surfaces with bioactive molecules to create smart materials for drug delivery and tissue engineering.
• Linker Synthesis for Drug Discovery: Serving as a key intermediate in the synthesis of cleavable or non-cleavable linkers used in targeted therapeutics.
• Immobilization Chemistry: Covalent attachment of biomolecules to solid supports (e.g., chips, beads, sensors) for assay development and biosensor fabrication.
• Nanoparticle Functionalization: Surface modification of liposomes, dendrimers, and inorganic nanoparticles to enable targeted delivery and imaging.
• Crosslinking Agent: Used in the preparation of crosslinked protein assemblies or polymer networks with defined properties.

Basic Information

Product Name	3-Maleimidopropionic Acid
CAS No.	54060-41-2
Molecular Formula	C7H7NO4
Molecular Weight	169.13 g/mol
Synonyms	3-Maleimidopropanoic Acid; Maleimidopropionic Acid; 3-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)propanoic Acid; 1-(2-Carboxyethyl)-1H-pyrrole-2,5-dione; β-Maleimidopropionic Acid; N-(2-Carboxyethyl)maleimide; MPA; 3-MPA
EINECS	258-920-9

Quality Control

Our 3-Maleimidopropionic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and bioconjugation applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive); allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.