Description

2-(1,1,2,3,3,3-Hexafluoropropoxy)Phenol is a specialized fluorinated phenolic compound, identified by CAS number 53998-00-8. This high-value intermediate is critical for synthesizing advanced materials and fine chemicals where the introduction of fluorine atoms imparts unique properties. It is primarily sought by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty polymer industries for developing novel compounds with enhanced stability and performance.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic ether motifs for improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the hexafluoropropoxy group can enhance lipophilicity and environmental persistence.
• Advanced Material Precursor: Serves as a monomer or modifier in the production of specialty polymers, liquid crystals, and coatings, contributing to thermal stability, chemical resistance, and low surface energy.
• Organic Electronics: Investigated as a component in the synthesis of materials for organic light-emitting diodes (OLEDs) and semiconductors due to the electron-withdrawing nature of the fluorinated side chain.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalysis, leveraging the phenolic oxygen and the unique steric/electronic profile of the fluorinated group.

Basic Information

Product Name	2-(1,1,2,3,3,3-Hexafluoropropoxy)Phenol
CAS No.	53998-00-8
Molecular Formula	C9H6F6O2
Molecular Weight	260.13 g/mol
Synonyms	Phenol, 2-(1,1,2,3,3,3-hexafluoropropoxy)-; 2-(Hexafluoropropoxy)phenol; 1-Hydroxy-2-(1,1,2,3,3,3-hexafluoropropoxy)benzene; o-(Hexafluoropropoxy)phenol; 2-Hydroxyphenyl hexafluoropropyl ether; HFP-Phenol; HFPO-Phenol derivative
EINECS	Contact for details

Quality Control

Every batch of 2-(1,1,2,3,3,3-Hexafluoropropoxy)Phenol is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, and NMR is supplied with each shipment. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound may be sensitive to moisture and strong bases; keep the container tightly sealed under an inert atmosphere for long-term storage. Keep away from heat and ignition sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.