Description

2-Amino-6-Methoxybenzotrifluoride is a high-value trifluoromethylated aniline derivative, serving as a critical building block in advanced organic synthesis. Its unique molecular structure, featuring both an amino and a methoxy group ortho to a benzotrifluoride core, makes it indispensable for creating complex, functional molecules. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Building block for creating specialty polymers, liquid crystals, and organic electronic materials that require specific optical or electronic properties.
• Dye and Pigment Manufacturing: Intermediate in the production of advanced, light-fast dyes and functional pigments.
• Cross-Coupling Reactions: Valuable substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination) for constructing complex nitrogen-containing heterocycles.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific research and scale-up projects.

Basic Information

Product Name	2-Amino-6-Methoxybenzotrifluoride
CAS No.	53982-03-9
Molecular Formula	C8H8F3NO
Molecular Weight	191.15 g/mol
Synonyms	2-Amino-6-methoxy-α,α,α-trifluorotoluene; 6-Methoxy-2-(trifluoromethyl)aniline; 2-Methoxy-6-(trifluoromethyl)aniline; 2-(Trifluoromethyl)-6-methoxyaniline; 2-Methoxy-α,α,α-trifluoro-m-toluidine; 1-Amino-3-methoxy-2-(trifluoromethyl)benzene; Benzenamine, 2-methoxy-6-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Amino-6-Methoxybenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.