Description

Sisomicin Sulfate is a semi-synthetic aminoglycoside antibiotic derived from sisomicin. This compound is valued for its potent bactericidal activity against a broad spectrum of Gram-negative and some Gram-positive bacteria. It is a critical active pharmaceutical ingredient (API) for the formulation of injectable antibiotic solutions and ophthalmic preparations. Pharmaceutical manufacturers and research institutions rely on high-purity Sisomicin Sulfate CAS NO 53776-71-9 for developing effective antimicrobial therapies.

Application

• Pharmaceutical API: Primary use as the active ingredient in injectable antibiotic formulations for systemic infections.
• Ophthalmic Solutions: Used in eye drops and ointments to treat bacterial conjunctivitis and other ocular infections.
• Veterinary Medicine: Employed in antibiotic preparations for treating bacterial infections in livestock and companion animals.
• Microbiological Research: Serves as a standard or reagent in antimicrobial susceptibility testing and mechanism of action studies.
• Reference Standard: Used in quality control laboratories as a chromatographic reference standard for assay and impurity testing.
• Topical Formulations: Incorporated into creams and gels for the treatment of localized skin and wound infections.

Basic Information

Product Name	Sisomicin Sulfate
CAS No.	53776-71-9
Molecular Formula	C19H37N5O7 • xH2SO4
Molecular Weight	Varies by sulfate salt stoichiometry. Sisomicin base: 447.53 g/mol.
Synonyms	Sisomicin Sulphate; Antibiotic 6640; Sch 13475; Sisomicin Sulfate Salt; 5-Deoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-β-L-lyxo-heptopyranosyl)-2-deoxy-D-streptamine sulfate; (2S,3R,4S,5S,6R)-4-Amino-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,4R,5R)-3,5-diamino-4-hydroxyoxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-6-(hydroxymethyl)oxane-3,5-diol sulfate
EINECS	Contact for details

Quality Control

Our Sisomicin Sulfate is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical applications, with typical purity levels exceeding 95% (by HPLC). We provide comprehensive Certificates of Analysis (COA) that include data for identity, assay, impurities, residual solvents, and microbiological tests. The product is compliant with major pharmacopeial guidelines, and custom synthesis to meet specific USP, EP, or BP monograph requirements is available.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
Water Content (KF)	≤ 10.0 %
pH (1% Solution)	3.5 - 5.5
Residue on Ignition	≤ 1.0 %
Related Substances (HPLC)	Total impurities ≤ 5.0%
Bacterial Endotoxins	< 1.0 EU/mg (for injectable grade)
Microbial Enumeration	Meets Ph. Eur. 2.6.12 / USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.