Description

Substance P (4-11) CAS NO 53749-60-3 is a bioactive peptide fragment derived from the neuropeptide Substance P, specifically encompassing amino acid residues 4 through 11. This fragment is of significant value in neuroscience and pharmacological research for studying the structure-activity relationships of Substance P and its receptor interactions. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on neurobiology, pain signaling pathways, and the development of novel therapeutic agents.

Application

• Neuroscience Research: A critical tool for investigating the role of Substance P in pain transmission, neurogenic inflammation, and central nervous system signaling.
• Receptor Binding Studies: Used in competitive binding assays to characterize and map the binding sites of the neurokinin-1 (NK-1) receptor.
• Structure-Activity Relationship (SAR) Analysis: Essential for determining the minimal active sequence of Substance P and designing peptide analogs with modified biological activity.
• Biochemical Assay Standard: Serves as a reference standard in HPLC, mass spectrometry, and other analytical methods for peptide quantification and purity assessment.
• Drug Discovery & Development: Used in high-throughput screening and preclinical studies to identify and evaluate potential antagonists or modulators of Substance P pathways.
• Cell Culture & In Vitro Studies: Applied in cellular models to study the effects of Substance P fragments on cell proliferation, cytokine release, and other physiological responses.

Basic Information

Product Name	Substance P (4-11)
CAS No.	53749-60-3
Molecular Formula	C44H68N14O10S
Molecular Weight	961.2 g/mol
Synonyms	Substance P Fragment 4-11; Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe; SP (4-11); H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-OH; Neurokinin P (4-11); [Arg1, Pro2, Lys3, Pro4, Gln5, Gln6, Phe7, Phe8]-Substance P
EINECS	Contact for details

Quality Control

Our Substance P (4-11) is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, and residual solvent levels are provided to ensure compliance with research-grade standards and support reproducible scientific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Within ± 10% of theoretical values
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.