Description

(D-Tyr5)-Lhrh is a synthetic peptide analog of the gonadotropin-releasing hormone (GnRH), featuring a D-tyrosine substitution at the fifth position. This structural modification is critical for enhancing its metabolic stability and receptor binding affinity, making it a valuable research tool in endocrinology and oncology. It is primarily utilized by pharmaceutical researchers, biotechnology companies, and academic institutions for the development of novel therapeutic agents and advanced diagnostic assays.

Application

• Endocrine Research: Used as a potent agonist/antagonist in studies of the hypothalamic-pituitary-gonadal axis.
• Oncology Research: Investigated for its role in hormone-dependent cancers, such as prostate and breast cancer.
• Peptide Drug Development: Serves as a key intermediate or reference standard in the synthesis of novel GnRH-based therapeutics.
• Biochemical Assays: Employed in receptor binding studies, enzyme-linked immunosorbent assays (ELISAs), and other in vitro diagnostic applications.
• Veterinary Medicine: Applied in research for fertility control and reproductive management in animals.
• Neuroscience Studies: Used to explore the neuromodulatory functions of GnRH and its analogs.

Basic Information

Product Name	(D-Tyr5)-Lhrh
CAS No.	53634-21-2
Molecular Formula	C₆₄H₈₃N₁₇O₁₃
Molecular Weight	1282.5 g/mol
Synonyms	(D-Tyr5)-Luteinizing Hormone-Releasing Hormone; (D-Tyr5)-GnRH; (D-Tyrosine-5)-LHRH; Gonadorelin (5-D-Tyrosine); pGlu-His-Trp-Ser-Tyr(D)-Gly-Leu-Arg-Pro-Gly-NH₂; LHRH (D-Tyr5); GnRH (D-Tyr5); (D-Tyr5)-Gonadotropin-Releasing Hormone
EINECS	Contact for details

Quality Control

Our (D-Tyr5)-Lhrh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Amino Acid Analysis	± 10% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.