Description

(D-His2)-LHRH is a synthetic analog of the gonadotropin-releasing hormone (GnRH), modified at the second histidine residue. This peptide is a critical research tool for studying hormone-receptor interactions and signal transduction pathways. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on endocrinology, oncology, and reproductive medicine.

Application

• Biomedical Research: Fundamental studies on GnRH receptor binding, activation mechanisms, and downstream cellular effects.
• Drug Discovery & Development: Serving as a reference standard or lead compound in the development of novel GnRH-based therapeutics for conditions like prostate cancer, endometriosis, and infertility.
• Endocrinology Studies: Investigating the hypothalamic-pituitary-gonadal axis, hormone regulation, and feedback mechanisms in model systems.
• Peptide Chemistry & Biochemistry: Used as a substrate or model compound in studies of peptide stability, modification, and structure-activity relationships (SAR).
• In Vitro Diagnostics (IVD): Potential use in the development and calibration of immunoassays for GnRH and related hormones.

Basic Information

Product Name	(D-His2)-LHRH
CAS No.	53634-19-8
Molecular Formula	C₆₄H₈₈N₁₈O₁₃
Molecular Weight	1341.5 g/mol
Synonyms	Des-Gly10, D-His2, Pro9-ethylamide-LHRH; [D-His2]-LHRH; [D-His2]-GnRH; Gonadorelin (D-His2) analog; Luteinizing Hormone-Releasing Hormone (D-His2) analog; [D-His2]-Luteinizing Hormone-Releasing Hormone; [D-His2]-LH-RH; (D-His2)-Gonadorelin
EINECS	Contact for details

Quality Control

Our (D-His2)-LHRH is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 8.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.