Description

(Sar1,Thr8)-Angiotensin II is a synthetic, biologically active peptide analog of the endogenous vasoconstrictor hormone Angiotensin II, featuring specific amino acid substitutions at positions 1 and 8. This modification is designed to enhance receptor binding affinity and metabolic stability, making it a critical tool for cardiovascular and renal system research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in studying hypertension, heart failure, and related endocrine pathways.

Application

• Biomedical Research: Used as a potent reference standard and agonist in studies of the renin-angiotensin system (RAS) and its role in blood pressure regulation.
• Pharmacological Assay Development: Serves as a key ligand for screening and characterizing Angiotensin II receptor (AT1 and AT2) antagonists and agonists in drug discovery.
• Signal Transduction Studies: Employed to investigate intracellular signaling pathways, including calcium mobilization and G-protein coupling, activated by angiotensin receptors.
• In Vitro & Ex Vivo Models: Applied in organ bath experiments and cell-based assays to model vascular contraction and cardiac hypertrophy.
• Metabolic Stability Research: The Sar1,Thr8 modification makes it a valuable compound for studying peptide degradation and designing more stable therapeutic analogs.
• Quality Control Standard: Used as an analytical reference standard in HPLC and MS for the quantification of angiotensin-related peptides in pharmaceutical preparations.

Basic Information

Product Name	(Sar1,Thr8)-Angiotensin II
CAS No.	53632-49-8
Molecular Formula	C₄₉H₆₉N₁₃O₁₂
Molecular Weight	1032.2 g/mol
Synonyms	Sar1,Thr8-Angiotensin II; [Sar¹,Thr⁸]-Angiotensin II; Angiotensin II, Sar¹,Thr⁸-; Asp-Arg-Val-Tyr-Ile-His-Pro-Thr; H-Asp-Arg-Val-Tyr-Ile-His-Pro-Thr-OH (Sar1,Thr8 substituted); DRVYIHPTh (single-letter code with substitution); ATII analog; Angiotensin II receptor agonist analog
EINECS	Contact for details

Quality Control

Our (Sar1,Thr8)-Angiotensin II is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and MS for identity confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.