Description

Dihydro-β-Methyldigoxin is a chemically modified cardiac glycoside derivative, specifically a hydrogenated and methylated analog of digoxin. This compound is of significant interest in pharmaceutical research and development due to its potential for altered pharmacokinetic and pharmacodynamic profiles compared to its parent molecule. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the development of novel cardiovascular therapeutics and in-depth pharmacological studies.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor or active pharmaceutical ingredient (API) in the development of next-generation cardiac glycoside medications.
• Cardiovascular Research: Used as a reference standard or experimental compound in biochemical and pharmacological research targeting sodium-potassium ATPase (Na⁺/K⁺-ATPase) inhibition.
• Metabolite Studies: Employed in analytical and metabolic studies to understand the biotransformation pathways of related digoxin analogs.
• Structure-Activity Relationship (SAR) Analysis: Critical for medicinal chemistry programs aiming to elucidate the impact of hydrogenation and methylation on the potency, selectivity, and toxicity profile of cardiac glycosides.
• Reference Standard: Used in quality control laboratories for the identification and quantification of related substances via chromatographic methods like HPLC.

Basic Information

Product Name	Dihydro-β-Methyldigoxin
CAS No.	53626-67-8
Molecular Formula	C₄₂H₆₆O₁₄
Molecular Weight	794.97 g/mol
Synonyms	β-Methyldigoxin Dihydro Derivative; Dihydro-β-Methyldigoxin; 4''-O-Methyl-β-acetyldigoxin Dihydro Derivative; β-Methyldigoxigenin Tetraglycoside Dihydro; Lanitop Dihydro Derivative; Medigoxin Dihydro Derivative; Digicor Dihydro Derivative
EINECS	Contact for details

Quality Control

Our Dihydro-β-Methyldigoxin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods, purity assay by HPLC, and control of related substances and residual solvents, to ensure it meets stringent specifications for research and development use. Certificates of Analysis (COA) documenting all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.