Description

H-Ala-Ala-Pro-Ala-OH is a high-purity synthetic tetrapeptide sequence composed of alanine and proline residues. This compound is a critical building block and research tool in peptide chemistry, valued for its defined structure and purity for advanced biochemical studies. It is primarily utilized by research institutions and pharmaceutical developers working on peptide synthesis, enzyme substrate specificity, and structure-activity relationship (SAR) investigations.

Application

• Peptide Synthesis Intermediate: Serves as a key fragment in the solid-phase or solution-phase synthesis of longer, more complex bioactive peptides.
• Biochemical Research: Used as a standardized substrate or inhibitor in enzymatic studies, particularly those involving proteases like dipeptidyl peptidase IV (DPP-IV) or proline-specific enzymes.
• Pharmaceutical Development: Acts as a reference standard or a core structural motif in the discovery and development of novel peptide-based therapeutics.
• Structure-Activity Relationship (SAR) Studies: Employed to investigate the impact of the Ala-Pro sequence on the biological activity, stability, and conformational properties of peptides.
• Academic Research: Utilized in university and institutional labs for teaching and fundamental research in peptide chemistry and molecular biology.

Basic Information

Product Name	H-Ala-Ala-Pro-Ala-OH
CAS No.	53620-20-5
Molecular Formula	C16H26N4O6
Molecular Weight	370.40 g/mol
Synonyms	Ala-Ala-Pro-Ala; AAPA; L-Alanyl-L-alanyl-L-prolyl-L-alanine; Tetrapeptide AAPA; H-Ala-Ala-Pro-Ala-OH; AAP-OH; (S)-2-((S)-2-((S)-2-((S)-2-Aminopropanamido)propanamido)pyrrolidine-1-carbonyl)propanoic acid
EINECS	Contact for details

Quality Control

Our H-Ala-Ala-Pro-Ala-OH is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.