Description

6-Nitro-7-Chloro-4-Hydroxyquinazoline is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its unique nitro-chloro-hydroxy substitution pattern on the quinazoline core makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those targeting kinase inhibition and other therapeutic pathways.
• Agrochemical Research: Used in the development of new herbicides and pesticides, leveraging its bioactive quinazoline scaffold.
• Material Science: Serves as a building block for creating advanced organic electronic materials and photoactive compounds.
• Dye & Pigment Synthesis: Utilized in the production of specialized dyes and pigments due to its chromophoric properties.
• Academic & R&D: Employed in university and corporate research laboratories for method development and exploratory chemistry.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	6-Nitro-7-Chloro-4-Hydroxyquinazoline
CAS No.	53449-14-2
Molecular Formula	C₈H₄ClN₃O₃
Molecular Weight	225.59 g/mol
Synonyms	4-Hydroxy-6-nitro-7-chloroquinazoline; 7-Chloro-6-nitro-4-quinazolinol; 6-Nitro-7-chloro-4(1H)-quinazolinone; 4(1H)-Quinazolinone, 7-chloro-6-nitro-; 7-Chloro-6-nitroquinazolin-4-ol; Quinazoline, 6-nitro-7-chloro-4-hydroxy-; 6-Nitro-7-chloro-4-hydroxyquinazoline
EINECS	Contact for details

Quality Control

Our 6-Nitro-7-Chloro-4-Hydroxyquinazoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.