Description

1-Carboxyglutamic Acid is a specialized amino acid derivative that plays a critical role in biological carboxylation processes. This compound is essential for the synthesis of proteins involved in blood coagulation and bone metabolism, making it a valuable biochemical building block. It is primarily utilized in advanced pharmaceutical research, diagnostic reagent development, and as a key intermediate in the synthesis of bioactive peptides and vitamin K-dependent proteins.

Application

• Pharmaceutical Intermediate: Key starting material for the synthesis of novel anticoagulants and bone metabolism regulators.
• Biochemical Research: Critical reagent for studying vitamin K-dependent carboxylation mechanisms and protein function.
• Diagnostic Reagents: Used in the development of assays for measuring undercarboxylated osteocalcin and other clinical markers.
• Peptide Synthesis: Important building block for incorporating post-translational modification sites into synthetic peptides.
• Nutraceutical Research: Investigated for potential applications in bone health and cardiovascular support formulations.
• Reference Standard: Serves as a high-purity analytical standard for quality control in related pharmaceutical manufacturing.

Basic Information

Product Name	1-Carboxyglutamic Acid
CAS No.	53445-96-8
Molecular Formula	C6H9NO6
Molecular Weight	191.14 g/mol
Synonyms	γ-Carboxyglutamic Acid; Gla; 4-Carboxyglutamic Acid; (2S)-2-Amino-4-carboxy-4-hydroxybutanedioic acid; 2-Amino-3-carboxy-3-hydroxyglutaric acid; 3-Carboxyglutamic Acid; U-19888
EINECS	Contact for details

Quality Control

Our 1-Carboxyglutamic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot undergoes comprehensive analytical testing including HPLC for purity, chiral analysis, and residual solvent screening. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, and we support compliance with relevant pharmacopeial standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: Specific range available
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.