Description

H-Leu-Gly-Oet Hcl is a protected dipeptide derivative, specifically the ethyl ester hydrochloride salt of the leucine-glycine dipeptide. This compound serves as a crucial building block in organic synthesis and peptide chemistry, offering a protected C-terminus for controlled chain elongation. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers involved in the development of novel peptide-based therapeutics, diagnostic agents, and biochemical tools.

Application

• Pharmaceutical Intermediates: Key raw material in the solid-phase and solution-phase synthesis of complex peptide drugs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a substrate or precursor in enzymatic studies and for investigating peptide structure-activity relationships (SAR).
• Proteomics & Diagnostics: Employed in the synthesis of labeled peptides for use as internal standards in mass spectrometry or as components in diagnostic assays.
• Cosmetic Peptides: Potential intermediate for the synthesis of bioactive peptides used in advanced skincare and cosmetic formulations.
• Academic & Industrial R&D: Fundamental building block for chemical libraries and novel compound discovery in medicinal chemistry programs.

Basic Information

Product Name	H-Leu-Gly-Oet Hcl
CAS No.	53375-57-8
Molecular Formula	C11H23ClN2O3
Molecular Weight	266.77 g/mol
Synonyms	L-Leucylglycine ethyl ester hydrochloride; Glycine, L-leucyl-, ethyl ester, hydrochloride; Ethyl L-leucylglycinate hydrochloride; Leu-Gly-OEt·HCl; H-Leu-Gly-OEt hydrochloride; N-(N-L-Leucylglycyl) ethyl ester hydrochloride; 2-[(2S)-2-Amino-4-methylpentanamido]acetic acid ethyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our H-Leu-Gly-Oet Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and residual solvent testing. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: Specific range available on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.