Description

Fmoc-Cys(Bzl)-Oh CAS NO 53298-33-2 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block, enabling the controlled and efficient incorporation of cysteine residues while protecting the thiol side chain from unwanted side reactions. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and CROs engaged in the development of therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected amino acid for the automated or manual synthesis of custom peptides.
• Therapeutic Peptide Development: Used in the research and production of peptide-based drugs targeting various diseases.
• Bioconjugation and Protein Engineering: Provides a protected cysteine handle for site-specific labeling, PEGylation, or the formation of disulfide bonds in engineered proteins.
• Chemical Biology Research: A key reagent for synthesizing peptide substrates, inhibitors, and tools for studying enzyme function and cellular processes.
• Material Science: Employed in creating peptide-based biomaterials, hydrogels, and surface coatings where controlled cysteine presentation is needed.
• Antibody-Drug Conjugate (ADC) Linker Chemistry: Can be utilized in the synthesis of specialized peptide linkers for ADCs.

Basic Information

Product Name	Fmoc-Cys(Bzl)-Oh
CAS No.	53298-33-2
Molecular Formula	C25H23NO4S
Molecular Weight	433.52 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-benzyl-L-cysteine; Fmoc-S-benzyl-L-cysteine; Fmoc-Cys(Bzl)-OH; N-Fmoc-S-benzylcysteine; (2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(benzylsulfanyl)propanoic acid; Fmoc-Cysteine(Bzl)-OH; Fmoc-L-Cys(Bzl)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Cys(Bzl)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept under anhydrous conditions in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.5%
Optical Rotation	-20.0° to -24.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.