Description

Boc-Leu-Oh·H2O CAS NO 53296-34-7 is a protected amino acid derivative, specifically N-tert-butoxycarbonyl-L-leucine monohydrate, widely used as a crucial building block in peptide synthesis. This compound is essential for researchers and manufacturers who require high-purity intermediates to ensure the fidelity and yield of complex peptide sequences. It is primarily utilized by the pharmaceutical, biotechnology, and academic research sectors for developing therapeutic peptides, diagnostic agents, and novel biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental reagent for the sequential coupling of amino acids, particularly in Fmoc/t-Bu strategies.
• Solution-Phase Peptide Synthesis: Used in the production of medium to long-chain peptides for research and commercial applications.
• Pharmaceutical Intermediates: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs) for peptide-based drugs.
• Bioconjugation: Employed to introduce the leucine residue with a protected amine into proteins, antibodies, or other biomolecules.
• Biochemical Research: Used in studies of protein structure-function relationships, enzyme substrates, and metabolic pathways.
• Combinatorial Chemistry: A valuable building block for creating diverse chemical libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	Boc-Leu-Oh·H2O
CAS No.	53296-34-7
Molecular Formula	C11H21NO5
Molecular Weight	247.29 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-leucine monohydrate; Boc-L-leucine monohydrate; (2S)-2-[[(2-Methylpropan-2-yl)oxycarbonyl]amino]-4-methylpentanoic acid monohydrate; N-Boc-L-leucine monohydrate; tert-Butoxycarbonyl-L-leucine monohydrate; Boc-Leu-OH.H2O; BOC-Leu; (S)-2-(tert-Butoxycarbonylamino)-4-methylpentanoic acid monohydrate
EINECS	Contact for details

Quality Control

Our Boc-Leu-Oh·H2O is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive applications like pharmaceutical research. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a corresponding Certificate of Analysis (COA). We adhere to relevant industry standards and can provide material tailored to specific project requirements, including research-grade and GMP-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]20/D	-25.0° to -28.0° (c=1 in AcOH)
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	6.0% - 8.0%
Heavy Metals	≤10 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.