Description

Loperamide CAS NO 53179-11-6 is a synthetic opioid receptor agonist specifically designed to act on the gastrointestinal tract. This compound matters significantly as a highly effective antidiarrheal agent, offering rapid relief by slowing intestinal motility and reducing fluid secretion. Pharmaceutical manufacturers and research institutions need it as the active pharmaceutical ingredient (API) for formulating over-the-counter and prescription anti-diarrheal medications.

Application

• Primary use as the Active Pharmaceutical Ingredient (API) in anti-diarrheal tablet, capsule, and liquid formulations.
• Key component in over-the-counter (OTC) medications for the symptomatic treatment of acute, non-specific diarrhea.
• Used in prescription medications for managing chronic diarrhea associated with conditions like Irritable Bowel Syndrome (IBS) and inflammatory bowel disease (IBD).
• Essential raw material in veterinary pharmaceuticals for treating diarrhea in animals.
• Critical material for pharmaceutical research and development, including formulation studies and bioavailability testing.
• Reference standard in analytical laboratories for quality control and method validation of finished drug products.

Basic Information

Product Name	Loperamide
CAS No.	53179-11-6
Molecular Formula	C29H33ClN2O2
Molecular Weight	477.04 g/mol
Synonyms	Loperamide Hydrochloride; 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutyramide; R-18553; Imodium; Loperamid; Lopéramide; Loperamida; Loperamidum
EINECS	Contact for details

Quality Control

Our Loperamide API is manufactured under strict quality management systems. Each batch is tested to meet or exceed relevant pharmacopeial standards such as USP, EP, and BP. Comprehensive testing includes identification, assay, impurity profiling, and residual solvent analysis. A Certificate of Analysis (COA) documenting full compliance with specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to protect from moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.