Description

3-Difluoromethoxy-4-Hydroxybenzaldehyde is a specialized aromatic aldehyde derivative featuring both difluoromethoxy and phenolic hydroxyl functional groups. This unique bifunctional structure makes it a high-value intermediate for the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in therapeutic areas requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the difluoromethoxy group can improve biological activity and environmental profile.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in display technologies.
• Polymer Chemistry: Employed as a monomer or cross-linking agent in the development of specialty polymers with specific thermal or chemical resistance properties.
• Organic Synthesis & Catalysis Research: A versatile substrate for methodological studies in organic chemistry, including novel fluorination and protection/deprotection strategies.

Basic Information

Product Name	3-Difluoromethoxy-4-Hydroxybenzaldehyde
CAS No.	53173-70-9
Molecular Formula	C8H6F2O3
Molecular Weight	188.13 g/mol
Synonyms	4-Hydroxy-3-(difluoromethoxy)benzaldehyde; 3-(Difluoromethoxy)-4-hydroxybenzaldehyde; Benzaldehyde, 3-(difluoromethoxy)-4-hydroxy-; 4-Formyl-2-(difluoromethoxy)phenol; 2-(Difluoromethoxy)-4-hydroxybenzaldehyde
EINECS	Contact for details

Quality Control

Every batch of 3-Difluoromethoxy-4-Hydroxybenzaldehyde is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements of research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our standard grades are developed with GMP-like controls suitable for non-clinical pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.