Description

Cyclo(-His-Pro) is a stable, cyclic dipeptide composed of the amino acids histidine and proline. This compound is of significant interest in biochemical and pharmaceutical research due to its role as a metabolite of thyrotropin-releasing hormone (TRH) and its potential biological activities. It serves as a valuable reference standard and key intermediate for researchers and manufacturers in the life sciences sector, particularly for studies in neuroendocrinology and metabolic regulation.

Application

• Pharmaceutical Reference Standard: Used for the identification, purity testing, and quantification of Cyclo(-His-Pro) in analytical methods development and quality control (QC) laboratories.
• Biochemical Research: Employed as a tool compound in metabolic and neurological studies to investigate its effects and interactions within biological systems.
• Peptide Synthesis Intermediate: Serves as a specialized building block for the synthesis of more complex peptides and peptidomimetics in medicinal chemistry.
• Diagnostic Reagent Development: Utilized in the formulation of assay kits and reagents for research into TRH metabolism and related pathways.

Basic Information

Product Name	Cyclo(-His-Pro)
CAS No.	53109-32-3
Molecular Formula	C11H14N4O2
Molecular Weight	234.26 g/mol
Synonyms	Cyclo(histidylproline); Cyclo(His-Pro); c(His-Pro); Histidylproline diketopiperazine; DKP-His-Pro; Cyclo(L-histidyl-L-prolyl); 3-(1H-Imidazol-4-ylmethyl)-6-(2-carboxyethyl)-2,5-piperazinedione; TRH Metabolite
EINECS	Contact for details

Quality Control

Our Cyclo(-His-Pro) is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.