Description

Cyclo(-Met-Pro) CAS NO 53049-06-2 is a high-purity cyclic dipeptide, specifically the diketopiperazine (DKP) derived from L-methionine and L-proline. This compound serves as a critical building block and intermediate in advanced pharmaceutical research and peptide synthesis. It is primarily utilized by R&D scientists and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic agents and studying biological pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex peptide-based drugs and active pharmaceutical ingredients (APIs).
• Protease Inhibitor Research: Used in biochemical research to study enzyme inhibition mechanisms due to its constrained cyclic structure.
• Peptidomimetic Scaffold: Acts as a rigid scaffold in medicinal chemistry for designing novel drug candidates with improved metabolic stability.
• Bioconjugation & Labeling: Employed in the development of diagnostic probes and targeted drug delivery systems.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Chemical Biology Tool: Utilized to probe protein-protein interactions and cellular signaling pathways.

Basic Information

Product Name	Cyclo(-Met-Pro)
CAS No.	53049-06-2
Molecular Formula	C10H16N2O2S
Molecular Weight	228.31 g/mol
Synonyms	Cyclo(Met-Pro); Cyclo(L-Methionyl-L-Prolyl); L-Methionyl-L-proline anhydride; 3-[(2S)-1-Methyl-2,5-dioxopyrrolidin-3-yl]methylsulfanylpropanoic acid; Methionine-Proline Diketopiperazine; Met-Pro DKP; (3S,8aS)-3-[(2-Methylsulfanylethyl)methyl]-1,4-diazabicyclo[4.3.0]nonane-2,5-dione; Cyclo(L-methionyl-L-prolyl) diketopiperazine
EINECS	Contact for details

Quality Control

Our Cyclo(-Met-Pro) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.