Description

5-Nitro-6-[[(2S,3S,4R)-2,3,4,5-Tetrahydroxypentyl]Amino]-1H-Pyrimidine-2,4-Dione is a specialized nucleoside analogue derivative with significant potential in advanced pharmaceutical research and development. This compound is valued for its precise stereochemistry and functional group arrangement, which are critical for modulating biological activity and studying enzyme interactions. It serves as a key synthetic intermediate or a potential active pharmaceutical ingredient (API) precursor for researchers in antiviral, anticancer, and metabolic disorder therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel nucleoside-based antiviral or anticancer agents.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving kinases, polymerases, or other nucleotide-processing enzymes.
• Medicinal Chemistry: Acts as a core scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Preclinical Development: Employed in the development and testing of new therapeutic candidates targeting DNA/RNA synthesis pathways.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Academic Research: Supports fundamental research in organic synthesis, chemical biology, and drug discovery at universities and institutes.

Basic Information

Item	Detail
Product Name	5-Nitro-6-[[(2S,3S,4R)-2,3,4,5-Tetrahydroxypentyl]Amino]-1H-Pyrimidine-2,4-Dione
CAS No.	52918-39-5
Molecular Formula	C9H14N4O8
Molecular Weight	306.23 g/mol
Synonyms	5-Nitro-6-((2S,3S,4R)-2,3,4,5-tetrahydroxypentyl)aminopyrimidine-2,4(1H,3H)-dione; 6-Amino-5-nitrouracil riboside derivative; 5-Nitro-6-(pentitol-1-yl-amino)uracil; (2S,3S,4R)-1-((5-Nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)amino)pentane-2,3,4,5-tetraol; 52918-39-5; Nitrated Aminopentitol Uracil
EINECS	Contact for details

Quality Control

Our 5-Nitro-6-[[(2S,3S,4R)-2,3,4,5-Tetrahydroxypentyl]Amino]-1H-Pyrimidine-2,4-Dione is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and identity confirmation via spectroscopic methods. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 98.0% ee (by Chiral HPLC)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.