Description

H-Pro-Met-Oh CAS NO 52899-08-8 is a high-purity, protected dipeptide building block, specifically L-Hydroxyprolyl-L-Methionine. This compound is a critical intermediate in the synthesis of complex peptides and peptidomimetics, offering precise control over stereochemistry and sequence. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require reliable, high-quality raw materials for drug discovery, development, and production.

Application

• Pharmaceutical Intermediate: A key building block in the solid-phase and solution-phase synthesis of therapeutic peptides targeting metabolic disorders, cardiovascular diseases, and central nervous system conditions.
• Peptidomimetic Research: Used in the design and development of peptidomimetics to enhance metabolic stability, bioavailability, and receptor selectivity of peptide-based drug candidates.
• Biochemical Research: Serves as a standard or reagent in enzymatic studies, protein-protein interaction assays, and structure-activity relationship (SAR) investigations.
• Cosmeceutical Peptides: Incorporated into the synthesis of bioactive peptides for advanced skincare formulations aimed at collagen synthesis and skin repair.
• Academic & Institutional R&D: Provides a foundational material for universities and research institutes exploring novel peptide chemistry and applications.

Basic Information

Product Name	H-Pro-Met-Oh
CAS No.	52899-08-8
Molecular Formula	C11H18N2O4S
Molecular Weight	274.34 g/mol
Synonyms	L-Hydroxyprolyl-L-methionine; (2S,4R)-1-[(2S)-2-Amino-4-(methylthio)butanoyl]-4-hydroxypyrrolidine-2-carboxylic acid; H-Pro-Met-OH; H-Pro-Met; Hyp-Met-OH; 4-Hydroxy-L-prolyl-L-methionine; L-Methionyl-trans-4-hydroxy-L-proline; Protected Dipeptide Hyp-Met
EINECS	Contact for details

Quality Control

Our H-Pro-Met-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and comprehensive identification tests. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and cGMP-grade material expectations for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.2%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.