Description

H-Pro-Leu-Oh CAS NO 52899-07-7 is a high-purity dipeptide derivative, specifically the protected form of the Proline-Leucine sequence. This compound serves as a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled construction of complex peptides and proteins. It is essential for research and development laboratories in the pharmaceutical, biotechnology, and life science sectors focused on novel therapeutic agents, diagnostic tools, and biochemical research.

Application

• Pharmaceutical Intermediates: Key raw material for the synthesis of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Biochemical Research: Used as a standard or reagent in enzymatic studies, metabolic pathway analysis, and protein structure-function research.
• Peptide Synthesis: A fundamental building block (amino acid derivative) in Fmoc/t-Boc solid-phase and solution-phase peptide synthesis protocols.
• Proteomics & Genomics: Employed in the development of substrates for protease assays and in the study of peptide-protein interactions.
• Cosmetic Peptides: Potential intermediate for the synthesis of bioactive peptides used in advanced skincare and cosmetic formulations.
• Academic & Industrial R&D: Serves as a crucial reagent for universities, contract research organizations (CROs), and chemical companies developing new peptide entities.

Basic Information

Product Name	H-Pro-Leu-Oh
CAS No.	52899-07-7
Molecular Formula	C11H20N2O3
Molecular Weight	228.29 g/mol
Synonyms	L-Prolyl-L-leucine; Pro-Leu; H-Pro-Leu-OH; L-Leucine, L-prolyl-; Proline-leucine dipeptide; NSC 334904; (S)-2-((S)-Pyrrolidine-2-carboxamido)-4-methylpentanoic acid; 2-[(2S)-2-Pyrrolidinylcarbonyl]amino]-4-methylpentanoic acid
EINECS	Contact for details

Quality Control

Every batch of H-Pro-Leu-Oh is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic and research applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.2%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.