Description

2-(Trifluoromethyl)-Pyrido[3,4-D]Pyrimidin-4(3H)-One is a high-value heterocyclic building block featuring a fused pyrido[3,4-d]pyrimidinone core substituted with a trifluoromethyl group. This compound is critical for medicinal chemistry research and development, offering unique electronic and steric properties that can significantly modulate the biological activity of lead molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel drug candidates, particularly in oncology and kinase inhibitor programs.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of small-molecule therapeutics, especially kinase inhibitors.
• Medicinal Chemistry Research: Used as a privileged scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• Agrochemical Development: Employed in the research of novel active ingredients for crop protection, leveraging the stability imparted by the trifluoromethyl group.
• Chemical Biology Probes: Acts as a core structure for designing molecular probes to study enzyme function and biological pathways.
• Material Science Research: Investigated as a potential component in the synthesis of advanced organic electronic materials due to its fused aromatic system.

Basic Information

Product Name	2-(Trifluoromethyl)-Pyrido[3,4-D]Pyrimidin-4(3H)-One
CAS No.	52833-58-6
Molecular Formula	C8H4F3N3O
Molecular Weight	215.14 g/mol
Synonyms	2-(Trifluoromethyl)-3,4-dihydro-4-oxopyrido[3,4-d]pyrimidine; 4(3H)-Pyrido[3,4-d]pyrimidinone, 2-(trifluoromethyl)-; 2-Trifluoromethylpyrido[3,4-d]pyrimidin-4(3H)-one; 2-Trifluoromethyl-4H-pyrido[3,4-d]pyrimidin-4-one; 2-(Trifluoromethyl)-4H-pyrido[3,4-d]pyrimidin-4-one; 52833-58-6; 2-Trifluoromethyl-3,4-dihydro-4-oxopyrido[3,4-d]pyrimidine
EINECS	Contact for details

Quality Control

Our production of 2-(Trifluoromethyl)-Pyrido[3,4-D]Pyrimidin-4(3H)-One adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide detailed Certificates of Analysis (COA) with each shipment, ensuring full traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is sensitive to strong alkalis and fluorides; ensure it is stored separately from such materials to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.