Description

Proflazepam CAS NO 52829-30-8 is a benzodiazepine derivative, a class of compounds known for their significant pharmacological activity. This high-purity chemical intermediate is crucial for research and development in the pharmaceutical sector, enabling the synthesis of novel therapeutic agents. It is primarily sought by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on central nervous system (CNS) drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Key building block in the research and synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a reference standard or precursor in structure-activity relationship (SAR) studies for CNS-targeted compounds.
• Biochemical Research: Employed in studies investigating the mechanism of action of benzodiazepines at GABA-A receptors.
• Process Development: Serves as a critical intermediate in scaling up synthetic routes for potential new chemical entities (NCEs).
• Analytical Reference Standard: Utilized in analytical method development and validation (e.g., HPLC, LC-MS) for quality control in pharmaceutical manufacturing.

Basic Information

Product Name	Proflazepam
CAS No.	52829-30-8
Molecular Formula	C₁₉H₁₇ClFN₃O
Molecular Weight	357.81 g/mol
Synonyms	Proflazepam; 7-Chloro-1-(cyclopropylmethyl)-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 7-Chloro-1-(cyclopropylmethyl)-5-(o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; Ro 07-5220; Ro 07-5220/000; Ro 07-5220/001; Ro 07-5220/002; Ro 7-5220
EINECS	Contact for details

Quality Control

Our Proflazepam is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and impurity profiling. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.