Description

Quisqualic Acid CAS NO 52809-07-1 is a potent, naturally occurring neuroexcitatory amino acid and a selective agonist for the AMPA and kainate subtypes of ionotropic glutamate receptors. Its unique pharmacological profile makes it a critical research tool for neuroscience and neuropharmacology. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors studying synaptic transmission, neurotoxicity, and developing treatments for neurological disorders.

Application

• Neuroscience Research: Used as a selective agonist to study AMPA and kainate receptor function, synaptic plasticity, and excitotoxicity in neuronal cell cultures and animal models.
• Neuropharmacology: A key tool compound for screening and evaluating potential neuroprotective agents, anticonvulsants, and drugs targeting glutamate pathways.
• Biochemical Assay Development: Serves as a standard and active component in receptor binding assays, calcium flux assays, and other high-throughput screening platforms.
• Toxicology Studies: Employed to model excitotoxic neuronal injury and investigate mechanisms of cell death relevant to stroke, trauma, and neurodegenerative diseases.
• Academic & Institutional Research: Fundamental reagent for university and government labs conducting basic research on glutamate neurotransmission and CNS signaling.
• Pharmaceutical R&D: Used in the discovery and preclinical development phases for novel therapeutics targeting neurological and psychiatric conditions.

Basic Information

Product Name	Quisqualic Acid
CAS No.	52809-07-1
Molecular Formula	C5H7N3O5
Molecular Weight	189.12 g/mol
Synonyms	Quisqualate; Quisqualic acid, L-; (S)-2-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)alanine; L-Quisqualic acid; NSC 336628; 2-Amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid; β-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine
EINECS	Contact for details

Quality Control

Our Quisqualic Acid is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) documenting identity, purity, and specific tests is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Optical Rotation	Specific rotation provided per COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.