Description

Z-Thr(Tbu)-Ome is a protected amino acid derivative, specifically the tert-butyl ether of threonine with Z (benzyloxycarbonyl) N-terminal protection and methyl ester C-terminal protection. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and sequential assembly of complex peptides. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity intermediates for the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of threonine residues into peptide chains.
• Pharmaceutical Research: Used in the research and development of novel peptide-based drugs, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation: Serves as a precursor for creating peptide tags or linkers used in antibody-drug conjugates (ADCs) and other bioconjugate platforms.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Biochemical Tool Development: Used to synthesize substrate analogs, enzyme inhibitors, and probes for studying protein function and interaction.
• Custom Peptide Services: A fundamental raw material for contract research and manufacturing organizations (CROs/CMOs) offering custom peptide synthesis.

Basic Information

Product Name	Z-Thr(Tbu)-Ome
CAS No.	52785-41-8
Molecular Formula	C16H23NO5
Molecular Weight	309.36 g/mol
Synonyms	N-Cbz-O-tert-butyl-L-threonine methyl ester; N-Benzyloxycarbonyl-O-tert-butyl-L-threonine methyl ester; Z-O-t-Butyl-L-threonine methyl ester; Z-Thr(OtBu)-OMe; Nα-Cbz-O-tert-butylthreonine methyl ester; L-Threonine, N-[(phenylmethoxy)carbonyl]-O-(1,1-dimethylethyl)-, methyl ester; (2S,3R)-Methyl 2-(((benzyloxy)carbonyl)amino)-3-((tert-butoxy)oxy)butanoate
EINECS	Contact for details

Quality Control

Our Z-Thr(Tbu)-Ome is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Specific Rotation	[α]20/D: Contact for details
Melting Point	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.