Description

Z-Tyr(Bzl)-Osu CAS NO 52773-66-7 is a protected tyrosine derivative, specifically the benzyl-protected N-carbobenzoxy-L-tyrosine N-hydroxysuccinimide ester. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and efficient incorporation of tyrosine residues while preventing unwanted side reactions. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the site-specific introduction of tyrosine into growing peptide chains.
• Therapeutic Peptide Production: Used in the research and GMP-scale manufacturing of peptide-based drugs, including hormones, antimicrobial peptides, and targeted therapeutics.
• Bioconjugation and Labeling: Serves as an activated ester for coupling tyrosine-containing peptides to carrier proteins, fluorescent dyes, or other molecules.
• Biochemical Research: Employed in academic and industrial R&D for studying protein-protein interactions, enzyme substrates, and receptor ligands.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse peptide libraries for drug discovery and screening.
• Antibody-Drug Conjugate (ADC) Development: Facilitates the synthesis of peptide linkers used in advanced targeted cancer therapies.

Basic Information

Product Name	Z-Tyr(Bzl)-Osu
CAS No.	52773-66-7
Molecular Formula	C26H24N2O7
Molecular Weight	476.48 g/mol
Synonyms	N-Carbobenzoxy-O-benzyl-L-tyrosine N-hydroxysuccinimide Ester; Z-O-Benzyl-L-tyrosine N-hydroxysuccinimide Ester; Nα-Cbz-O-benzyl-L-tyrosine N-succinimidyl ester; Cbz-Tyr(Bzl)-OSu; Z-Tyr(Bzl)-OSu; N-(Benzyloxycarbonyl)-O-benzyl-L-tyrosine N-hydroxysuccinimide Ester; (S)-2-(((Benzyloxy)carbonyl)amino)-3-(4-(benzyloxy)phenyl)propanoic acid 2,5-dioxopyrrolidin-1-yl ester
EINECS	Contact for details

Quality Control

Our Z-Tyr(Bzl)-Osu is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric purity, and spectroscopic identification (NMR, IR). We provide full traceability and detailed Certificates of Analysis (COA) with every shipment to ensure compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.