Description

5,5-Difluorolysine is a fluorinated derivative of the essential amino acid L-lysine, characterized by the substitution of two fluorine atoms at the 5-position. This structural modification is crucial for its role as a key building block in medicinal chemistry and biochemical research, enabling the study of enzyme mechanisms and protein interactions. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on developing novel therapeutics, diagnostic probes, and advanced biochemical tools.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of fluorinated peptide-based drugs and protease inhibitors.
• Biochemical Research: Used as a stable, non-hydrolyzable analog of lysine to investigate enzyme kinetics and binding sites.
• Proteomics & Labeling: Serves as a building block for creating affinity tags and chemical probes for protein labeling and pull-down assays.
• PET Tracer Development: Potential use in the synthesis of precursors for Positron Emission Tomography (PET) imaging agents.
• Material Science: Incorporation into specialty polymers and biomaterials to alter surface properties and stability.

Basic Information

Product Name	5,5-Difluorolysine
CAS No.	52683-82-6
Molecular Formula	C6H12F2N2O2
Molecular Weight	182.17 g/mol
Synonyms	5,5-Difluoro-L-lysine; (2S)-2,6-Diamino-5,5-difluorohexanoic acid; 5,5-Difluorolysine hydrochloride (salt forms); DFK; 5,5-Difluoronorleucine analog; Lysine, 5,5-difluoro-
EINECS	Contact for details

Quality Control

Our 5,5-Difluorolysine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.