Description

Insulin, Des-Gly(A1)- is a synthetic insulin analog where the glycine residue at position A1 of the A-chain has been removed. This modification is of significant interest in biochemical and pharmaceutical research for studying insulin's structure-activity relationships and receptor binding mechanisms. It serves as a critical intermediate and reference standard for the development and analysis of novel insulin-based therapeutics. This high-purity compound is essential for researchers and manufacturers in the fields of endocrinology, diabetes research, and peptide drug development.

Application

• Biochemical Research: Used as a key reference standard and intermediate in studies investigating insulin's structure, function, and receptor interaction mechanisms.
• Pharmaceutical Development: Serves as a critical starting material or intermediate in the synthesis and research of novel insulin analogs and peptide-based therapeutics.
• Analytical Standard: Employed in high-performance liquid chromatography (HPLC) and mass spectrometry (MS) for method development, validation, and quality control of insulin-related products.
• Metabolic Studies: Utilized in in vitro and ex vivo research models to understand the biological activity and metabolic pathways of modified insulin molecules.
• Diagnostic Reagent Manufacturing: Acts as a component in the development of immunoassays and diagnostic kits for measuring insulin and related peptides.

Basic Information

Product Name	Insulin, Des-Gly(A1)-
CAS No.	52627-23-3
Molecular Formula	C254H377N65O76S6
Molecular Weight	~5777.5 g/mol
Synonyms	Des-Gly(A1)-Insulin; Insulin (human) lacking Gly(A1); A1-Desglycine Insulin; Human Insulin Des-Gly(A1); Insulin A-chain(2-21), B-chain(1-30); Insulin analog (Des-Glycine A1); [Des-GlyA1]-Insulin
EINECS	Contact for details

Quality Control

Our Insulin, Des-Gly(A1)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay purity, related substances, and peptide content. We support compliance with relevant regulatory frameworks for research materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 10.0%
Peptide Content (UV)	≥ 80.0%
Biological Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.