Description

Angiotensin I/II (4-8) is a bioactive peptide fragment derived from the angiotensinogen cascade, specifically corresponding to residues 4 through 8 of the Angiotensin I and II sequences. This compound is a critical research tool for studying the renin-angiotensin system (RAS), which is central to cardiovascular regulation, blood pressure control, and fluid balance. It is primarily utilized by researchers and developers in pharmaceutical R&D, biochemical research, and diagnostic assay development to investigate peptide-receptor interactions, enzyme kinetics, and potential therapeutic pathways.

Application

• Biomedical Research: Fundamental studies on the structure, function, and signaling pathways of the renin-angiotensin system (RAS).
• Drug Discovery & Development: Serving as a reference standard, intermediate, or pharmacophore model for designing novel cardiovascular or renal therapeutics.
• Enzyme Activity Assays: Used as a specific substrate to study the activity and inhibition of key enzymes like angiotensin-converting enzyme (ACE).
• Diagnostic Development: Acting as a critical antigen or calibrator in the development of immunoassays (e.g., ELISA) for detecting angiotensin-related biomarkers.
• Peptide Chemistry & Synthesis: Employed as a building block or reference compound in custom peptide synthesis and analytical method development.
• Academic & Institutional Research: Supporting investigations in physiology, pharmacology, and molecular biology related to hypertension and metabolic disorders.

Basic Information

Product Name	Angiotensin I/II (4-8)
CAS No.	52530-60-6
Molecular Formula	C26H41N9O6
Molecular Weight	575.67 g/mol
Synonyms	Angiotensin (4-8); Ile-His-Pro-Phe-His; IHPFH; Angiotensin I Fragment 4-8; Angiotensin II Fragment 4-8; H-Ile-His-Pro-Phe-His-OH; L-Isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidine
EINECS	Contact for details

Quality Control

Our Angiotensin I/II (4-8) is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide full traceability and documentation. Certificates of Analysis (COA) detailing all specification results are available upon request to ensure compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Peptide Content	≥ 80.0%
Amino Acid Composition	± 10% of theoretical
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.