Description

Insulin, Dodecoy(A1-B29)- CAS NO 52499-58-8 is a chemically modified insulin derivative where the amino acid at position A1 and B29 has been replaced with a dodecanoyl group. This modification is critical for altering the pharmacokinetic profile of the hormone, primarily to extend its duration of action and enhance stability. It serves as a key intermediate and reference standard in advanced pharmaceutical research and development, particularly for creating novel long-acting insulin analogs. This product is essential for researchers and manufacturers in the biopharmaceutical sector focused on diabetes treatment and metabolic disorder therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel, long-acting insulin analog prodrugs.
• Biomedical Research: Used as a reference standard in studies investigating the structure-activity relationship (SAR) of modified insulins.
• Drug Delivery System Development: Employed in R&D for creating sustained-release formulations and conjugate-based delivery platforms.
• Metabolic Studies: Utilized in preclinical research to understand the impact of fatty acid acylation on insulin's binding affinity and clearance.
• Analytical Standard: Acts as a high-purity calibrant in chromatographic (HPLC, LC-MS) and spectroscopic analyses for quality control.

Basic Information

Product Name	Insulin, Dodecoy(A1-B29)- CAS NO 52499-58-8
CAS No.	52499-58-8
Molecular Formula	C257H383N65O77S6
Molecular Weight	~5808.5 g/mol
Synonyms	Dodecanoyl-Insulin; NαA1,NεB29-Didodecanoyl-Insulin; A1,B29-Didodecanoyl Insulin; Fatty Acid Acylated Insulin; Long-Acting Insulin Analog Intermediate; Insulin Dodecanoyl Derivative; INS-Dodecoyl(A1-B29); B29-Myristoyl-Des(B30) Insulin (related analog)
EINECS	Contact for details

Quality Control

Our Insulin, Dodecoy(A1-B29) is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Specifications are aligned with research-grade standards, and Certificates of Analysis (COA) detailing results for assay, related substances, and identity tests are provided. We support compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, keep desiccated at the recommended temperature.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 8.0%
Biological Activity	Assessed per customer method

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.