Description

Insulin, Des-Ala- CAS NO 52499-36-2 is a synthetic peptide analog of insulin, specifically lacking the alanine residue at the A-chain N-terminus. This modification makes it a critical intermediate and reference standard in advanced pharmaceutical research and development. It is primarily utilized by biopharmaceutical companies and research institutions focused on diabetes treatment, metabolic studies, and novel insulin analog design.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control of insulin-based therapeutics.
• Biochemical Research: Serves as a key intermediate in structure-activity relationship (SAR) studies to understand insulin receptor binding and signaling.
• Metabolic Disorder Studies: Employed in preclinical research to investigate the mechanisms of diabetes and evaluate new therapeutic approaches.
• Peptide Synthesis Intermediate: Acts as a building block for the chemical synthesis of more complex, modified insulin analogs with tailored properties.
• Diagnostic Kit Development: Utilized in the production and calibration of immunoassays and diagnostic tests for insulin detection.

Basic Information

Product Name	Insulin, Des-Ala-
CAS No.	52499-36-2
Molecular Formula	C254H377N65O76S6
Molecular Weight	~5778.4 g/mol
Synonyms	Desalanine Insulin; Insulin (Human) Des-Ala; Des-Ala-Insulin; Insulin Des-Ala; Desalanine-Insulin; A1-Desalanine Insulin; Insulin A-Chain(1-21), B-Chain(1-30)-peptide (human); Human Des-Ala Insulin
EINECS	Contact for details

Quality Control

Our Insulin, Des-Ala- is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) detailing purity, peptide content, and related substances are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content (UV)	≥ 80.0%
Water Content (KF)	≤ 5.0%
Acetic Acid Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.