Description

Insulin, Des-Gly(A1)-Des-Phe(B1)- is a specific, chemically modified insulin derivative where the glycine at position A1 and the phenylalanine at position B1 have been removed. This modification is of significant interest in biochemical and pharmaceutical research for studying insulin's structure-activity relationships and receptor binding mechanisms. It serves as a critical intermediate and reference standard in the development of novel insulin analogs and therapeutic peptides. This high-purity compound is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on metabolic disease research and next-generation diabetes therapies.

Application

• Biochemical Research: Used as a key reference compound for investigating the structural determinants of insulin activity and receptor interaction.
• Pharmaceutical R&D: Serves as a crucial intermediate in the synthesis and development of novel insulin analogs with modified pharmacokinetic profiles.
• Metabolic Studies: Employed in in vitro and in vivo studies to understand the specific roles of the A1 and B1 residues in insulin signaling and glucose metabolism.
• Analytical Standard: Acts as a high-purity standard for HPLC, LC-MS, and other analytical methods used in peptide characterization and quality control.
• Peptide Chemistry: Provides a valuable template for studying peptide folding, stability, and chemical modification techniques.

Basic Information

Product Name	Insulin, Des-Gly(A1)-Des-Phe(B1)-
CAS No.	52499-35-1
Molecular Formula	C252H381N65O76S6
Molecular Weight	~5708.4 g/mol
Synonyms	Des-Gly(A1)-Des-Phe(B1)-Insulin; Insulin (human) Des-Gly(A1)-Des-Phe(B1)-; A1,B1-Des-di-insulin; Insulin derivative (A1-Gly, B1-Phe缺失); [Des-GlyA1, Des-PheB1]-Insulin
EINECS	Contact for details

Quality Control

Our Insulin, Des-Gly(A1)-Des-Phe(B1)- is manufactured under strict quality systems suitable for research and development applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (typically >95%), to ensure consistency and reliability. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, related substances, and residual solvents. We adhere to high standards of quality control to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Water Content (Karl Fischer)	≤ 8.0%
Peptide Content	≥ 80.0%
Biological Activity	Assessed by specific assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.