Description

L-Glutamic Acid 1-Ethyl Ester is a key protected derivative of the essential amino acid L-glutamic acid, widely utilized as a versatile building block in organic synthesis and peptide chemistry. Its primary value lies in the ethyl ester group, which serves as a protective moiety for the carboxylic acid functionality, enabling selective reactions during complex molecular assembly. This high-purity intermediate is critically needed by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel peptides, active pharmaceutical ingredients (APIs), and biochemical reagents.

Application

• Peptide Synthesis: A fundamental protected amino acid derivative for solid-phase and solution-phase peptide synthesis, enabling the controlled construction of complex peptide chains.
• Pharmaceutical Intermediates: Serves as a crucial precursor in the synthesis of various drug candidates and active pharmaceutical ingredients (APIs) targeting neurological and metabolic pathways.
• Biochemical Research: Used as a standard or reagent in enzymatic studies, metabolic pathway analysis, and neuroscience research related to glutamatergic systems.
• Fine Chemical Production: Acts as a chiral building block for the manufacture of specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.
• Protecting Group Strategy: The ethyl ester group provides a standard protecting strategy for the γ-carboxyl group of glutamic acid, which can be selectively removed under mild conditions.

Basic Information

Product Name	L-Glutamic Acid 1-Ethyl Ester
CAS No.	52454-78-1
Molecular Formula	C7H13NO4
Molecular Weight	175.18 g/mol
Synonyms	L-Glutamic acid 5-ethyl ester; Ethyl L-glutamate; (S)-2-Aminopentanedioic acid 5-ethyl ester; H-Glu(OEt)-OH; L-Glutamic acid γ-ethyl ester; Ethyl (S)-2-aminopentanedioate; 5-Ethoxy-5-oxo-L-norvaline
EINECS	257-904-7

Quality Control

Our L-Glutamic Acid 1-Ethyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot is subjected to comprehensive analytical testing, including chiral purity verification, to meet the exacting standards required for pharmaceutical and research applications. Certificates of Analysis (COA) detailing specific results for identity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]	+22.0° to +26.0° (c=1 in H2O)
Loss on Drying	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.