Description

Z-Gly-Gly-His-OH is a synthetic tripeptide derivative, specifically a protected form of the Gly-Gly-His sequence. This compound serves as a crucial intermediate and building block in advanced peptide synthesis and biochemical research. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for developing novel therapeutic agents and studying metal-binding peptide interactions.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of longer, more complex peptide-based drug candidates.
• Biochemical Research: Used in studies of peptide-metal ion interactions, particularly with copper, due to the presence of the histidine residue.
• Protease Substrate/Analogue: Serves as a model substrate or inhibitor in enzymatic studies related to proteolytic activity.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for peptide characterization.
• Material Science: Investigated for the development of bio-inspired materials and catalytic systems.

Basic Information

Product Name	Z-Gly-Gly-His-OH
CAS No.	52396-73-3
Molecular Formula	C₁₉H₂₅N₅O₇
Molecular Weight	435.43 g/mol
Synonyms	N-Carbobenzoxy-Glycyl-Glycyl-L-Histidine; Z-Gly-Gly-L-His-OH; CBZ-Gly-Gly-His-OH; Nα-CBZ-Glycyl-Glycyl-L-Histidine; Benzyloxycarbonyl-Glycyl-Glycyl-L-Histidine; Glycyl-Glycyl-L-Histidine N-Carboxybenzyl Derivative; (S)-2-(2-(2-((Benzyloxy)carbonylamino)acetamido)acetamido)-3-(1H-imidazol-4-yl)propanoic acid
EINECS	Contact for details

Quality Control

Our Z-Gly-Gly-His-OH is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.